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Pharmaceutical Powder Dosing Equipment

API making equipment must observe rigorous quality control standards across the entire manufacturing process. The pharmacodynamic properties of active pharmaceutical ingredients API make them highly sensitive to their environment, making API manufacturing and production a tightly regulated field.

Active pharmaceutical ingredients (API)

The click and puff of inhalers is a universal signal for respiratory conditions. Inhalers quickly grew into preferred drug delivery systems for asthma and COPD. Dry inhaler powder formulation produces a more stable drug than liquid dosage forms. Moreover, inhaler ingredients are more resistant to bacterial growth.

Dry inhaler powder

Used in the pharmaceutical industry to produce tablets and capsules, among others, pharmaceutical granules are made to enhance the uniformity and flow of powder, increase the density of the blend and reduce dust and, therefore, toxic exposure. The choice of the granulation process, whether it is wet, dry, or direct compression, as well as the selection of appropriate pharmaceutical granulation equipment, depends on the specific drug being formulated.

Pharmaceutical granules

Chili powder

Around a third of your natural protein composition is collagen. But the human body still finds good use for more of it, whether to reinforce joints or aid digestion. Collagen powder processing breaks the chains of amino acids into smaller units, allowing them to be consumed at higher concentrations without changing your diet.

Collagen powder

First commercially sold baby food was created by Henri Nestlé when he combined cow milk with sugar and grains. Baby food industry has since grown to offer everything from whole wheat infant cereals to ramen-flavored baby food. From infant formula to fruit puree, choosing the baby food processing equipment is related to the type of baby food you want to make.

Baby Food

Baking powder is perhaps the best-known secret of baking. The leavening agent forms bubbles in dough and batter to give muffins, cakes, and no-yeast pizza their tempting lift. First developed in the 19th century, baking powder production turned baking into the home activity we know today.

Baking powder

In 1682, Denis Papin found a method to remove collagen from animal bones, discovering gelatin. But it was the inventor Peter Cooper who developed gelatin powder processing. In 1845 he secured his invention with US patent 4084 for a dessert of gelatin powder called “portable gelatin”.

Gelatin powder

Food powder is the result of drying and pulverizing food. It has been around since the astronauts when out to space. Fruits have a short shelf life and are difficult to preserve due to their high water content.  Fruit powder processing allows you to keep the nutrients of the fruits for a longer time, even off-season.

Fruit powder

The fishmeal powder market forecast shows that its global market value will reach USD 10.3 billion by 2025. Expanding since 2019, at an annual growth rate of 6.5%. Fishmeal powder production has strong business potential with the increase of applications in animal feed, pet food, and fortified foods.

Fishmeal powder

Forged metal objects appear seamless, simple items. But as the use of metals changed over time and constructions became more intricate with additive manufacturing, a new way of processing materials surfaced. Metal powder manufacturing replaces the classic blacksmithing techniques, reducing scrap waste in the meantime. The final metal products, however, retain that shiny allure of the archetypal metal pieces.

Metal powder

Powder detergent is one of the most widespread washing solutions used in the laundry of fabrics. Since they contain no water, powder detergents are lighter than liquid detergent or pods, which results in cheaper transport and, thus, a more affordable choice for the end consumer. Although manufacturers can formulate their powder detergents differently, the detergent powder production process relies on a combination of builders, surfactants, and enzymes.

Powder detergent

It took the scientific community almost 70 years to agree on the name ‘protein’ and discard the popular alternative, proteid. But protein powder processing still needed another five decades to be commercialized in the 1950s. Once extraction and purification could be industrialized, protein powder soon became a basic staple supplement.

Protein powder

Basically, to make milk powder, you need to remove the water content from the liquid milk and turn it into powder. How to do it? After pasteurizing and homogenizing the milk, milk’s water content is removed through filtration, evaporation, and drying. You have then to cool and sieve it before filling the containers. Here's how you get milk powder.

Milk powder

Looking beautiful is hard work. Queen Elizabeth I knows this well. Just think she used so many cosmetics and makeup containing toxic materials, especially lead-based face powder, that she even died from them. Today fortunately, you no longer need lead to make face powder. Simply mix pigments, fillers, dry and wet binders, and compress the mixture using a powder compacting press. Then the face powder is ready to be applied using a powder puff.

Face powder

Curry powder

Cocoa minus its fats makes cocoa powder. Deriving this culinary element follows a careful process of roasting and winnowing cocoa beans before the nibs are ground, generating a liquor. The butter that results from melting fats is removed to leave the ingredient that defines recipes from brownies to a Frostbite cocktail.

Cocoa powder

Everything tastes like porridge, the saying goes. That may be an exaggeration, but in theory, reaction flavors could make everything taste the same. Thankfully, flavorists and chemists in the flavor industry are more inventive than that, and colorful process flavors treat our taste buds to a broad palette of sensations, flavors and aromas.

Reaction flavors

Flour processing technology has changed drastically since the days of the millstone pulled by a mule. But demand for more refined flour means that the production process is now slower than with more rudimentary techniques. When mixed with water, protein in wheat flour form an elastic gluten structure, giving bakery products their irresistible fluffiness.

Flour

Ground cinnamon

Available as a standalone system

Very accurate for small doses

Modular design makes it versatile

Gravimetric Dosing Systems

Industrial feeders and hoppers are used to provide a consistent, regulated flow of material to the production line for further processing. Feeders and hoppers are generally used in the industry in conjunction with other processing machines like crushers, dryers, conveyors, and mixers. Considerations for choosing a suitable feeding system include the physical state and particle size of the infeed, the output volumetric flow rate required and the type of connection to be made with the processing machinery.

Industrial hoppers

Micro dosing systems

Chemical

Food

Pharmaceutical

Dosing equipment

Dosing systems are a line of hoppers, feeders, filling machines, and checkweighers that operate in sync to dispense materials accurately. Dosing is an essential feature of the packaging process, whether you’re filling shampoo bottles or tea bags. But dosing equipment is critical for formulations, too, particularly in the pharmaceutical and chemical industries. Imprecise dosing may cause quality degradation in the best-case scenario. In the worst scenario, it creates serious health risks.

Dosing

Connect directly with world leading manufacturers of Dosing equipment and find technology to build or improve your production line.

Dosing - Making.com

Due to their potential hazardous nature, chemicals are classified for proper identification and safety during production. Chemical classification depends on their properties, structures and functions. In the chemical industry, you can regard them as basic chemicals such as acids, chemical products to produce plastic materials and finished chemicals for use in cosmetology. As a manufacturer or engineer, you want to know their reactivity when using chemical processing equipment.

Chemicals

Our food chain starts in the soil, growing crops and livestock. But between the fields and the stores, there is a line of industrial food processing equipment. Processes may be as minimalistic as cleaning fruit and as complex as homogenizing milk alternatives made from pressed legumes. In each case, processing technology is an important link in the food production chain.

Pharmaceutical powders provide longer shelf life and better stability than liquid dosage forms. But the processing of pharmaceutical powders is crucial for growing segments besides pharmacy. Functional foods and cosmetics formulated with active ingredients and excipients depend on powdered forms to fulfill their promises.

Pharmaceutical powder

Pharmaceutical developments walk side by side with health advances to provide new medicines, treatments, and therapies that have increased life quality and extended life expectancy by years. Pharmaceutical manufacturing equipment helps deliver products to a great deal of the population, but there’s a significant share that doesn’t benefit from them yet. Over 2 billion people cannot get the medicines they need, according to the United Nations Industrial Development Organization, and local production might be a way to provide for these people.

Pharmaceuticals

The building blocks of matter have driven the imagination of philosophers, scientists, and artists for millennia. But, for manufacturers, these elements have a more concrete existence as powders. Powder processing technology conditions these primary materials to create a vast range of products, from chemicals and foods to pharmaceuticals and ceramics.

Powder

Process

Continuous

Weighing

solid

If you need to process high value food, pharmaceuticals or chemicals, there is no room for error when measuring. Having a reliable measuring equipment to

Gravimetric powder microdosing 0.400 - 2 g - Making.com

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The marketplace for finding innovative production technology

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Vitamin C is an essential nutrient, but the human species lost the ability to produce it biologically during the course of evolution. Instead, we source the substance either from whole foods or vitamin C manufacturing. The chemical characteristics of the natural nutrient and processed compound are the same, but supplements offer higher concentrations, especially to persons with nutrient deficiencies.

Vitamin C

Powders and granules are commonly dosed for the manufacturing of pharmaceuticals, nutraceuticals and high-value foods. Highly accurate dosing and tight

Gravimetric powder microdosing 2 - 100 g - Making.com

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Highly accurate

Check weighing function for the ejection of overweight dosages

Optional protection for explosive environments: II 2 D / -  III C T 125°C

Cocoa production and the cocoa industry uses industrial processing technology to process and manufacture high quality cocoa products in many different forms. Did you know that cacao cultivation goes back centuries - to be specific, about 5300 years? This plant, with its long history, is also known for its versatile usage. From cocoa nips to cocoa butter, cocoa becomes a base to produce multiple products, ranging from food products to cosmetics. As you may already know, chocolate products are all made from cocoa as well. Hence, depending on what you intend to produce as the end product, as well as your recipe, your cocoa processing equipment line may change.

Cocoa

Micro-dosing powders of high-value food or chemical products can be challenging when high precision and zero error is required. You need a highly accurate

Fast gravimetric powder microdosing 50 - 200 g - Making.com

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Dyes lend color to the things we consume. The foods we eat, the clothes we wear, and even the keyrings that separate your bunch all have a splash of dye added. Historically, colors were extracted from the natural world, but that process has been replaced by processing technology. Dye manufacturing equipment produces colors that are high in definition and consistency.

Compact, hygienic design with no moving parts

Volumetric and volumetric-gravimetric dosing of powders

Capable of dosing powders <1-500 mg

Inline monitoring of dose quantity

Parallel and multiple dosing possible

Aseptic filling equipment is crucial for sensitive products, as they need to be filled into their primary packaging in an environment free from contamination caused by harmful bacteria, viruses, or other microorganisms. Choosing an aseptic filling solution requires consideration of the physical form of the product, the type of primary packaging, the volume to be dosed per package, and the production speed. Aseptic fillers are widely used for cleaning, filling, and sealing pre-sterilized vials, cartridges, ampoules, and syringes in the pharmaceutical industry. Aseptic filling is also used in the food industry to process for example, dairy products that need harmful bacteria's minimized, or ensure shelf-stable products that do not require refrigeration. In these industries, aseptic equipment is integrated into the production line for maximum isolation and sterilization. And, can either be configured as an automated or manual process, depending on standards that the products require.

Aseptic filling equipment

Pharmaceutical powders in metered doses demand maximum filling precision. This is particularly challenging with materials in the micro-gram range. Fine

Powder micro-dosing system - Making.com

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Capable of dosing powder in the range of 200 - 100 mg

Real-time monitoring of dose quantity

High level of accuracy and repeatability

Balancing speed and accuracy in powder dosing is crucial to fulfilling production viability. But, in the case of small powder quantities, achieving that

High-speed powder dosing system - Making.com

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Economical design

Compact system with no moving parts

Precise powder dosing in (>100 g) range

Multiple dosing system with independent feeding

Dosing multiple powders in a batch process is time inefficient, especially when handling small quantities of materials. But dose precision is a more

Accurate multiple dosing system for powders - Making.com

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It is strange how two tablets can belong to the same but at the same time to a different category depending on how the tablet itself is classified. For example, chewable tablets and effervescent tablets have two different routes of administration but both belong to the category of uncoated tablets. Uncoated tablets are prepared by compression of granules in which no coating is added after compression. They may be single-layer or multi-layer tablets.

Uncoated tablets

Painting as an integral aspect of the human tradition dates to thousand years ago. Of the many properties of the product, the drying time is important to consumers. The thickness of the paint and environmental factors like humidity affect this parameter. Paint manufacturing equipment must include a humidity test chamber to assess the behavior of paint under different weather conditions.

Paint

After pasteurizing and homogenizing the raw milk, you need to ferment the milk with starter culture until solid curds and liquid whey is formed. Then, the liquid whey goes through a filtration and drying process to turn it into powder. Before sending it to packaging, flavorings are usually added.

Whey protein

Only about 6% of the soy produced globally is directly consumed by humans, typically as edamame beans, tofu, or soy milk.  More than three-fourths of global soy production goes to animal feed. The rest is processed by soybean meal technology into oils or used for biofuels and other industrial processes.

Soybean meal

A solution for any powder dosing application

No internal agitation which can cause a material degradation

Very easy and fast to clean

Low power consumption and long service life

Atex zone 21 Certificated

Volumetric dosing systems

Parenteral preparations refer to drugs using non-oral means of administration. Injectables, such as needles and syringes, are used to deliver a drug into the systemic circulation directly in the veins, muscles, under the skin, or in the tissue.

These parenteral formulations are pharmaceutical dosage forms that have strict regulations on being sterile, pyrogen-free, and free from visible particulate matter including reconstituted sterile powders. Solutions, suspensions, emulsions, and gels with APIs intended for administration by injection are usually supplied in vials, ampoules, pre-filled syringes, or pens to facilitate ease of use.

Injectables

Liquid dosage forms are designed for easy absorption. The body quickly carries the active ingredients through the system and triggers the required response. But the greatest advantage of this medicinal type is its flexibility in formulation and dispensation. From lotions and syrups to drops and sprays, liquid solutions can be adapted to different administration routes including parenteral, topical, and oral. The fundamental liquid dosage manufacturing process involves dissolving or suspending solutes in a fluid. But that is not enough. A precise blend of excipients is needed to make the medicine go down.

Liquid dosage forms

Pigments are colorants that are not soluble in the host material and scatter light and are therefore opaque. Pigments can be organic or man-made and derive from animals, plants, rocks or minerals and metal oxides, like for example titanium oxide.

Pigment

Can it be said that we live in the Plastic age? Basically, yes. From pillows over toothbrushes, and packaging to utensils, plastic is a widely used material in our day-to-day lives. But what is it? Plastics are synthetic or semi-synthetic materials built of polymers that are easily shaped into various structures with the help of plastic processing equipment such as extruders and molders.

Plastics

Among all dosage forms in use today, tablets constitute the most common one. They are pharmaceutical solid dosage forms containing active ingredients and excipients such as diluents, binders, glidants, and lubricants. Using tablet making equipment, these solid dosage forms are made by compression of granules or powder blends and then shaped by molding.

Tablets

R&amp;D

Batch

Conveyor systems are used for moving materials from one location to another. Considerations for choosing a suitable industrial conveying system include the nature of the product, its physical state, the desired conveying rate, and sensitivity of the product to heat and mechanical shock. Conveying equipment is used in the food, pharmaceutical, chemical, biomass, and mineral industries to move materials around a warehouse as well as to transport bulk powders, granules, and grains for processing and filling. These types of systems are usually automated and there is a wide variety of solutions to choose when it comes to the type of conveyor. Types include screw, gravity, chain, roller and belt conveyors.

Conveying

Industrial feeding systems allows you to control the flow of solid bulk materials throughout the manufacturing line. After loading your material onto the vibrating hopper, a screw at the base drives it out in uniform doses to the next stage of processing. New feeding technologies are designed to deal with challenges of powders clumping together in the hopper (bridging and ratholing) that interrupt the outflow. Common feeder systems include centrifugal feeders, vibratory feeders as well as elevator, linear and pneumatic feeders.

Feeding

The varying properties of dry powder products mean that specialized feeders are required for dispensing them into the feed screw. Bad-flowing and

Feeder with flexible wall hopper - Making.com

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The billions of microbes living in our gut have a significant impact on gastrointestinal health, mood, and behavior. Every individual develops their microbiome community. Probiotic processing technology makes sure that harmful bacteria never outnumber good citizens.

Probiotics

The two-piece capsule is a visual shorthand for all types of medical remedies. Advances in technology have made the production of hard-gelatin capsules a convenient delivery method for drugs and other ingested substances. But the simple solution requires micrometric precision to be manufactured to the proper pharmaceutical standards.

Hard gelatin capsules

The nonproprietary name for HPMC – hydroxypropyl methylcellulose – is such a mouthful that it has two abbreviations. Hypromellose is the other one. The non-ionized material offers a safe alternative to gelatin capsules, especially as most common API and excipients are suitable HPMC capsule ingredients.

HPMC capsules

Microtablets range between 1 and 4 millimeters, making the dosage form an excellent delivery system in polypharmacy. The size of the products makes them easier pills to swallow, but microtablets production brings a unique set of complexities.

Microtablets

Multilayer tablets are a popular fixed-dose combination (FDC) offering a range of release profiles for effective drug delivery. Multilayer tablet technology solves challenges to API consistency, allowing manufacturers to develop formulations from incompatible ingredients while optimizing the release profile for immediate release and controlled release.

Multi-layer tablets

When taking a tablet, it is usually the job of our stomach to break down the medication to make it ready to be absorbed into the bloodstream. However, some drugs are not meant to be dissolved in the stomach because the acidic pH of the stomach can disintegrate the drug, making it no longer effective. Using tablet coating equipment that applies a polymer barrier to the tablet makes it possible to protect it from stomach acidity.

Enteric Coated Tablets

The fizz of effervescent tablets is commonly associated with a vitamin C boost. But the soluble pill is an excellent drug delivery method for pediatric and geriatric patients. Sometimes referred to as carbon tablets, manufacturing effervescent tablets binds biocarbonate and citric acid that produce the smooth hiss as they dissolve in liquid.

Effervescent tablets

Pre-packaged liners reduce operator error

Continuous liner design increases containment reducing risk of contamination and employee exposure

Interfaces directly with a wide array of existing process equipment

Can also be used with bag in / bag out processes with rigid isolators and flexible enclosures

A flexible containment solution prevents product loss and ensures that personnel is not exposed to harmful substances by locking in the product as it is transferred from one container to another. The choice of a containment system depends on the physical state of the product, the type of container from which the product is being transferred, and the type of container to which it is being moved. Flexible containment solutions are widely used in the pharmaceutical, food, and chemical industries to comply with health and safety regulations.

Flexible containment solutions

A flexible intermediate bulk container is an industrial container designed for the transportation and storage of dry, flowable products in bulk packages. Selection of big bag filling equipment requires consideration of the type of particles to be packaged, type of bag to be used, filling weight/volume per bag, and production volume. Big bag filling equipment is used in the food industry for packaging seeds, spices, salt, and starch. In the pharmaceutical industry it is used for packaging of active ingredients; in the chemical industry for the filling of bulk chemicals, fertilizers, pigments, and plastic granules.

Flexible intermediate bulk containers

Logistics

Packaging

The essential objectives of containment systems are personnel protection and preventing the release of toxic or infectious material into the environment. Containment is also used to prevent a product or sample from contamination by the external environment. In the chemical and pharmaceutical industries, containment solutions are used to protect the personnel from the leaking of airborne particles of hazardous substances, as powders or liquids are handled or transferred during processing.

Containment

Handling

At last, you reached the final stage of processing your product - welcome to the packing world! Packing preserves and protects a product from damage, spoilage, and contamination while it makes its way from the production line to the consumer or further production. Depending on which industry your products belong to, the type of primary packaging equipment can change drastically. You need to pay careful attention to products with chemicals or hazardous substances since they can be potentially dangerous to human health.

Packing

A disposable drum liner for continuous production of powders.

Powdered products are handled every day in the pharmaceutical and bioprocess industries and an efficient means of filling drums while maintaining

Flexible contained powder discharge into drums - Making.com

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Pharmaceutical Powder Dosing Equipment

Which pharmaceutical powder dosing technology do you need?

Gravimetric powder microdosing 0.400 – 2 g

Gravimetric powder microdosing 2 – 100 g

Fast gravimetric powder microdosing 50 – 200 g

Powder micro-dosing system

High-speed powder dosing system

Accurate multiple dosing system for powders

Feeder with flexible wall hopper

Flexible contained powder discharge into drums

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